특히 생 약독화 재조합 플라비바이러스를 포함하는 안정한 백신 조성물 및 그의 제조 방법

• Main Authors: GHODEKAR SHASHIKANT JANARDAN, SONAR ROHIT BAPURAV, DHERE RAJEEV MHALASAKANT, MEHLA RAJEEV, KUMAR VINIT, BARASKAR SANDEEP DINKAR, YEOLEKAR LEENA RAVINDRA
• Format: Patent
• Language: Korean
• Published: 22.07.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

특히, 생 약독화된 재조합 플라비바이러스, 보다 바람직하게는 생 약독화된 재조합 뎅기 바이러스, 적어도 하나의 탄수화물, 적어도 하나의 아미노산을 포함하는 안정한 동결건조된 면역원성 조성물은 특히 급속한 냉동-건조 처리를 받을 수 있고, 조성물은 바이러스 생존능, 면역원성 및 안정성을 포함하여 바이러스의 요망되는 특징을 보존한다. 상기 면역원성 조성물은 보존제, 중합체 및 계면활성제가 없다. 상기 안정한 동결건조된 면역원성 조성물을 제조하는 방법. Stable lyophilized immunogenic compositions include inter alia live attenuated recombinant flaviviruses, more preferably live attenuated recombinant dengue viruses, at least one carbohydrate, at least one amino acid and is particularly amenable to rapid freeze-drying treatments wherein, the composition preserves desired characteristics of a virus, including virus viability, immunogenicity and stability. The immunogenic composition is devoid of preservatives, polymers and surfactants. The methods for manufacturing the stable lyophilized immunogenic compositions are also provided.