TRK MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS

식의 화합물:및 약제학적으로 허용가능한 그의 염, 여기서 링 A, 링 B, W, m, D, R, R, R, R, 및 Z은 본 명세서에서 정의된 바와 같음, 은 Trk 키나제의 저해제이고 통증, 암, 염증, 신경퇴행성 질환 및 특정의 감염성 질환의 치료에서 유용하다. The present invention relates with a process for preparing compounds of Formula I:and pharmaceutically acceptable salts thereof, wherein ring A, ring B...

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Main Authors JIANG YUTONG, YANG HONG WOON, KOLAKOWSKI GABRIELLE R, CONDROSKI KEVIN RONALD, HAAS JULIA, SEO JEONGBEOB, ZHAO QIAN, ANDREWS STEVEN WADE
Format Patent
LanguageEnglish
Korean
Published 14.07.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:식의 화합물:및 약제학적으로 허용가능한 그의 염, 여기서 링 A, 링 B, W, m, D, R, R, R, R, 및 Z은 본 명세서에서 정의된 바와 같음, 은 Trk 키나제의 저해제이고 통증, 암, 염증, 신경퇴행성 질환 및 특정의 감염성 질환의 치료에서 유용하다. The present invention relates with a process for preparing compounds of Formula I:and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R, R, R, R, and Z are as defined herein, and which are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases;intermediates of formula IIused in the preparation of compounds of formula I and the compound for use in the treatment of the diseases mentioned above of the following formula:
Bibliography:Application Number: KR20207019372