A pharmaceutical composition for suppressing uremia and a health functional food for the prevention and improvement of kidney disease

• Main Authors: PARK JUNG SUN, KIM CHANG SEONG, BAE EUN HUI, MA SEONG KWON, KIM SOO WAN
• Format: Patent
• Language: English; Korean
• Published: 23.06.2020
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The present invention relates to a pharmaceutical composition and health functional food. More specifically, the present invention relates to a composition for inhibiting uremia and health functional food in which the mitochondrial membrane potential of renal tubular cells is weakened by uremic substances, the expression of IAP which inhibits apoptosis is reduced, ER stress is induced, and the expression of MAPK and NF-κB is also increased to cause apoptosis, wherein the composition for inhibiting uremia and health functional food use the inhibition of all of these apoptosis processes by α-lipoic acid. 본 발명은 약학조성물 및 건강기능성식품에 대한 것으로, 보다 구체적으로는 요독 물질에 의하여 신세뇨관 세포의 미토콘드리아 막 전위가 약해지고, 세포사멸을 억제하는 IAP의 발현이 감소하며, ER stress를 유발하고 MAPK와 NF-κB의 발현 또한 증가시켜 세포사멸이 일어나는데, 이러한 모든 세포사멸 과정을 α-리포산(Lipoic acid)이 억제하는 것을 이용한 요독증억제용조성물 및 건강기능성식품에 관한 것이다.