Bio-Marker Composition for Prediction of Drug for lung cancer Sensitivity Estimation Method for Prediction of Drug for lung cancer Sensitivity using Bio-Marker Composition and Diagnosing Chip for Detection of Bio-Marker Composition for Prediction of Drug for lung cancer Sensitivity

• Main Authors: LEE SUN HO, CHOI ICWON, JUNG, JONG SUN, HONG JONG HUI
• Format: Patent
• Language: English; Korean
• Published: 20.05.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; VINEGAR; WINE

The present invention relates to a biomarker composition for determining lung cancer drug reactivity. In the biomarker composition composed of a combination of markers containing a variation that modulates gene expression for determining the reactivity to a lung cancer drug, the biomarker composition for determining lung cancer drug reactivity comprises 2_217847583_C_T (marker 1), 2_71424561_G_GT (marker 2), 2_217847883_G_A (marker 3), 2_217848003_A_G (marker 4), and 17_81206909_A_C (marker 5). According to the present invention, through biomarkers for drugs related to lung cancer, it is possible to predict the susceptibility of each target genotype for a lung cancer drug, and thus effective preliminary verification is conducted not only in the field of personalized medicine but also in the discovery of new drug candidates. 본 발명은 폐암 약물 반응성 판단을 위한 바이오 마커 조성물에 관한 것으로, 본 발명은 폐암 약물에 대한 반응성 판단을 위하여, 유전자 발현을 조절하는 변이가 포함된 마커들의 조합으로 구성되는 바이오 마커 조성물에 있어서, 상기 바이오 마커 조성물은, 2_217847583_C_T(마커1), 2_71424561_G_GT(마커2), 2_217847883_G_A(마커3), 2_217848003_A_G(마커4) 및 17_81206909_A_C(마커5)를 포함하여 구성되는 폐암 약물 반응성 판단을 위한 바이오 마커 조성물을 포함한다. 이와 같은 본 발명에 의하면, 본 발명에서는 폐암 관련 약물들에 대한 바이오 마커들을 통해, 폐암 약물에 대하여, 대상자 유전형질별 민감성을 예측할 수 있으므로, 개인별 맞춤의학 분야뿐만 아니라 신약 후보군 발굴에 효과적인 예비검증이 이루어지도록 하는 효과가 있다.