5--2-2--5--4--4---4[2--2--]--24- CRYSTALLINE FORMS OF 5-CHLORO-N2-2-ISOPROPOXY-5-METHYL-4-PIPERIDIN-4-YL-PHENYL-N4[2-PROPANE-2-SULFONYL-PHENYL]-PYRIMIDINE-24-DIAMINE

• Main Authors: WAYKOLE LILADHAR MURLIDHAR, KARPINSKI PIOTR H, FENG LILI, GONG BAOQING
• Format: Patent
• Language: English; Korean
• Published: 14.04.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

본 발명은 5-클로로-N-(2-이소프로폭시-5-메틸-4-(피페리딘-4-일-페닐)-N-2-(이소프로필술포닐)페닐)-2,4-디아민의 특정 결정질 형태를 기술한다. 본 발명은 추가로 상기 결정질 형태를 제조하는 방법, 상기 결정질 형태를 포함하는 제약 조성물, 및 질환 치료를 위해 상기 결정질 형태 및 제약 조성물을 사용하는 방법에 관한 것이다. The present invention describes a process for preparing 5-chloro-N-(2-isopropoxy-5-methyl-4-(piperidin-4-ylphenyl)-N-2-(isopropylsulfonyl)phenyl)-2,4-diamine di-hydrochloride salt and crystalline form of 5-chloro-N-(2-isopropoxy-5-methyl-4-(piperidin-4-ylphenyl)-N-2-(isopropylsulfonyl)phenyl)-2,4-diamine.