Method for preparing liver organoid comprising stem cell derived from liver and use thereof

• Main Authors: YOO JONG MAN, HAHN SOO JUNG
• Format: Patent
• Language: English; Korean
• Published: 31.03.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TESTING; VINEGAR; WINE

The present invention relates to a method for producing an organoid comprising liver derived stem cells and a use thereof. The organoid produced by the method activates cytochrome P450, a drug metabolism enzyme in the body, as a model to replace cell and animal experiments, thereby being used as a drug metabolism platform. 간 유래 줄기세포를 포함하는 오가노이드의 제조방법 및 이의 용도에 관한 것으로, 상기 방법에 의해 제조된 오가노이드는 세포 및 동물실험을 대체할 수 있는 모델로서 체내 약물 대사 효소인 시토크롬 P450을 활성화시켰는바 약물대사 플랫폼으로 이용할 수 있다.