PROCESS FOR THE PROPARATION OF CONTRAST MEDIUM IOMEPROL

• Main Authors: OH GI BUM, OH YOUNG SEON, CHA YOUNG NAM, LEE YOUNG KEUN, KIM JUNG JIN
• Format: Patent
• Language: English; Korean
• Published: 26.03.2020
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to a method for preparing an X-ray contrast agent iomeprol and, more specifically, to a method for preparing iomeprol by adding an inorganic base, an inorganic chloride, a solvent, etc. to 5-(2-hydroxyacetamido)-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (1b) to induce N-methylation reaction, thereby enabling easy separation and removal of inorganic salts generated during the reaction, without treatment with an ion exchange resin, while reducing the conventional production time, and minimization of the amount of reaction impurities. 본 발명은 X선 조영제 이오메프롤의 제조방법에 관한 것으로, 보다 상세하게는 5-(2-히드록시아세트아미도)-N, N'-비스(2, 3-디히드록시프로필)-2, 4, 6-트리아이오도이소프탈아미드(1b)에 무기염기, 무기염화물, 용매 등을 첨가하고 N-메틸화 반응을 수행함으로써, 기존의 제조 시간을 단축하면서 반응 중에 생성되는 무기염을 이온교환수지 처리없이 용이하게 분리 제거할 수 있고, 반응 불순물을 최소화할 수 있는 이오메프롤의 제조방법에 관한 것이다.