B형 간염 바이러스의 표면항원 억제제

• Main Authors: SUN FEI, CHEN SHUHUI, HU YANBIN, DING CHARLES Z
• Format: Patent
• Language: Korean
• Published: 13.03.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

본 발명은 신규한 B형 간염 표면항원 억제제인 11-옥소-7,11-다이히드로-6H-벤조[f]-피리도[1,2-d]-[1,4]옥사제핀-5-카르복실산 유도체에 관한 것으로, 구체적으로 화학식 V의 화합물 또는 이의 약학적으로 허용 가능한 염, 및 B형 간염 바이러스성 간염 치료에서의 화학식 V의 화합물 또는 이의 약학적으로 허용 가능한 염과 약학적 조성물의 용도를 개시하였다. [화학식 V] Disclosed in the present invention is a new 11-oxo-7,11-dihydro-6h-benzo-[f]pyrido[1,2-d][1,4]azepine oxepin-10-carboxylic acid derivative serving as a hepatitis B virus surface antigen inhibitor. Specifically disclosed are a compound represented by formula (V) or a pharmaceutically acceptable salt thereof, and applications of the compound represented by formula (V) or the pharmaceutically acceptable salt thereof and a pharmaceutical composition thereof in the treatment of viral hepatitis B.