FGFR 저해제의 결정형 및 이의 제조 방법

• Main Authors: TAO MING, XIA MICHAEL, WANG DENGJIN, PAN YONGCHUN, HAN WAYNE, JIA ZHONGJIANG, ZHOU JIACHENG, SHI CHONGSHENG ERIC, LI QUN
• Format: Patent
• Language: Korean
• Published: 07.02.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

본 개시내용은 N-{[2'-(2,6-디플루오로-3,5-디메톡시페닐)-3'-옥소-2',3'-디하이드로-1'H-스피로[사이클로프로판-1,4'-[2,7]나프티리딘]-6'-일]메틸}아크릴아미드의 고체 형태, 이의 제조 방법, 및 그것의 제조에서의 중간체에 관한 것이고, 이들은 FGFR-연관된 또는 매개된 질환 예컨대 암의 치료에서 유용하다. The present disclosure relates to solid forms of N-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3′-oxo-2′,3′-dihydro-1′H-spiro[cyclopropane-1,4′-[2,7]naphthyridin]-6′-yl]methyl}acrylamide, methods of preparation thereof, and intermediates in the preparation thereof, which are useful in the treatment of the FGFR-associated or mediated diseases such as cancer.