Materials for preventing or treating Alzheimer's disease and compositions comprising same

• Main Authors: KIM JUWAN, YOON KEEJUNG
• Format: Patent
• Language: English; Korean
• Published: 07.01.2020
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TESTING; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

본 발명은 Ttyh1 유전자의 발현 억제제 또는 Ttyh1 단백질의 활성 억제제를 유효성분으로 포함하는 알쯔하이머성 치매의 예방 또는 치료용 조성물에 대한 것으로, 보다 상세하게는 알쯔하이머성 치매의 원인 중 하나인 아밀로이드 베타의 생성을 감소시키기 위하여, 감마-세크레타아제(γ-secretase)의 활성과 관계된 Ttyh1의 발현을 조절하는 물질 및 상기 물질의 스크리닝 방법에 대한 것이다. The present invention relates to a composition comprising a Ttyh1 gene expression inhibitor or a Ttyh1 protein activity inhibitor, and a method of preventing or treating Alzheimer's disease using the same.