VLP VLP STABILIZED VACCINE COMPOSITIONS

• Main Author: KAPRE SUBHASH V
• Format: Patent
• Language: English; Korean
• Published: 02.01.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

본 발명은 바이러스 백신 및 박테리아 백신의 안정화 조성물 및 안정화 방법에 관한 것이다. 본 발명의 백신은 VLP를, 예를 들어, 당 알코올 (예, 소르비톨) 및 분해된 젤라틴 등의 안정화제와 함께 포함한다. 바람직하게는, 젤라틴은 10,000 kD 이하의 평균 분자량을 가진다. 상기한 백신은 실질적으로 개선된 열 안정성 뿐만 아니라 장기 안정성을 가진다. 또한, 본 발명은 본 발명의 백신 제조 방법 및 본 발명의 백신을 환자에게 투여하는 방법에 관한 것이다. The invention is directed to compositions and methods for the stabilization of viral and bacterial vaccines. Vaccines of the invention are contained in VLPs with stabilizing agents such as, for example, sugar alcohols (e.g., sorbitol) and degraded gelatins. Preferably the gelatin has an average molecular weight of 10,000 kilodaltons or less. These vaccines have a substantially improved thermostability as well as long term stability. The invention is also directed to the manufacture of a vaccine or the invention and methods for the administration of a vaccine of the invention to patients.