변형된 대사를 갖는 면역 세포 및 이의 용도

• Main Authors: PATAKAS AGAPITOS, COYLE NANCY, LEEK MICHAEL, LONDON TIMOTHY, HANNIGAN ADELE, COSIMO EMILIO, SCOTT ANGELA
• Format: Patent
• Language: Korean
• Published: 23.12.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

SLC1A5, SLC1A5의 아이소폼, 또는 대안적인 트립토판 또는 글루타민 수송체를 과발현시키도록 구성된 변형된 T 세포가 기술된다. 또한, 질환, 특히, 암의 치료에서의 이러한 변형된 T 세포의 용도, SLC1A5를 과발현시키는 변형된 T 세포를 선택하는 방법, 및 이러한 변형된 T 세포를 제공하기 위한 핵산 및 벡터가 기술된다. A modified T cell is described which is adapted to overexpress SLC1A5, an isoform of SLC1A5 or an alternative tryptophan or glutamine transporter. Further described is the use of such modified T cells in the treatment of disease, in particular cancer, methods to select modified T cells which overexpress SLC1A5 and nucleic acids and vectors to provide for such modified T cells.