ERK1/2 억제제로서의 6-피리미딘-이소인돌 유도체

본 발명은 화합물 (2R)-2-(6-{5-클로로-2-[(옥산-4-일)아미노]피리미딘-4-일}-1-옥소-2,3-디히드로-1H-이소인돌-2-일)-N-[(1S)-1-(3-플루오로-5-메톡시페닐)-2-히드록시에틸]프로판아미드 및 특히 화합물의 신규 물리적 형태, 화합물 및 방법에 사용하기 위한 합성 중간체의 제조 방법, 화합물을 함유하는 신규 제제, 뿐만 아니라 화합물의 치료 용도에 관한 것이다. This invention relates to the compound (2R)-2-(6-{5-chloro-2-[(oxan-4-yl)amino]p...

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Main Authors ADAMCZYK BOZENA EWA, LINDLEY COLIN THOMAS, MELLING ROBERT CRAIG, SCARATI MIRKA, WILSHER NICOLA ELIZABETH, READER MICHAEL, BAGULEY PAUL ANTHONY, SAUNDERS MARK HENRY
Format Patent
LanguageKorean
Published 20.12.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:본 발명은 화합물 (2R)-2-(6-{5-클로로-2-[(옥산-4-일)아미노]피리미딘-4-일}-1-옥소-2,3-디히드로-1H-이소인돌-2-일)-N-[(1S)-1-(3-플루오로-5-메톡시페닐)-2-히드록시에틸]프로판아미드 및 특히 화합물의 신규 물리적 형태, 화합물 및 방법에 사용하기 위한 합성 중간체의 제조 방법, 화합물을 함유하는 신규 제제, 뿐만 아니라 화합물의 치료 용도에 관한 것이다. This invention relates to the compound (2R)-2-(6-{5-chloro-2-[(oxan-4-yl)amino]pyrimidin-4-yl}-1-oxo-2,3-dihydro-1H-isoindol-2-yl)-N-[(1S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl]propanamide, and in particular to novel physical forms of the compound, a process for preparing the compound and synthetic intermediates for use in the process, and novel formulations containing the compound, as well as therapeutic uses of the compound.
Bibliography:Application Number: KR20197033128