AAV 벡터를 기반으로 하는 인플루엔자 백신

• Main Authors: KOLKMAN JOOST, TRETIAKOVA ANNA P, FRIESEN ROBERT, NASO MICHAEL, WILSON JAMES M, LIMBERIS MARIA P, WANG QIANG
• Format: Patent
• Language: Korean
• Published: 05.12.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

AAV 반전 말단 반복부 서열 및 4개의 상이한 면역글로불린 영역 (a), (b), (c) 및 (d)를 암호화하는 적어도 하나의 핵산 서열을 포함하는 벡터 게놈을 내부에 패키징한 AAV 캡시드를 갖는, 비복제 재조합 아데노-연관 바이러스(rAAV). 상기 rAAV-발현된 면역글로불린은 인플루엔자 A 및 인플루엔자 B에 대한 수동 면역화를 제공하는 데 유용하다. 또한 본 명세서에는 rAAV를 함유하는 조성물이 기술된다. 환자에게 인플루엔자에 대해서 백신 접종하는 방법이 제공된다. A non-replicating recombinant adeno-associated associated virus (rAAV) having an AAV capsid having packaged therein a vector genome which comprises AAV inverted terminal repeat sequences and at least one nucleic acid sequence encoding four different immunoglobulin regions (a), (b), (c) and (d) is provided. The rAAV-expressed immunoglobulins are useful for providing passive immunization against influenza A and influenza B. Also described herein are compositions containing the rAAV. Methods of vaccinating patients against influenza are provided.