CD3 CD3- CD3-BINDING MOLECULES CAPABLE OF BINDING TO HUMAN AND NON-HUMAN CD3

• Main Authors: JOHNSON LESLIE S, HUANG LING
• Format: Patent
• Language: English; Korean
• Published: 11.09.2019
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

본 발명은 사람 및 비-사람 CD3에 결합할 수 있는 CD3-결합 분자, 및 특히 비-사람 포유동물 (예를 들어, 게먹이 원숭이)의 CD3과 교차 반응성인 이러한 분자에 관한 것이다. 본 발명은 또한 암, 자가 면역 및/또는 염증성 질환 및 다른 질병의 치료에 이러한 항체 및 항원-결합 단편의 사용에 적용된다. The present invention relates to CD3 -binding molecules capable of binding to human and non-human CD3, and in particular to such molecules that are cross-reactive with CD3 of a non-human mammal (e.g., a cynomolgus monkey). The invention also pertains to uses of such antibodies and antigen-binding fragments in the treatment of cancer, autoimmune and/or inflammatory diseases and other conditions.