에리불린 및 그 중간체의 제조방법

• Main Authors: ORUGANTI SRINIVAS, BASU DEBJIT, PALVAI PRAPULLA KUMAR, EDA VISHNU VARDHANA VEMA REDDY, DAVIDSON ROBERT WEN MING, SARVESH KUMAR, PENUMANDLA RAJA GOPAL, DAHANUKAR VILAS HARESHWAR, MEEK GRAHAM ANDREW, FOX MARTIN EDWARD, LLOYD MICHAEL CHARLES, MANDAL AMIT KUMAR, RAO PALLAVI, WARREN SARAH ANN
• Format: Patent
• Language: Korean
• Published: 15.07.2019
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

본 발명은 에리불린 또는 약학적으로 허용되는 그의 염과 같은 할리콘드린 B 유사체를 제조하기 위한 중간체로서 유용한 화학식(II)의 테트라하이드로푸란 화합물, 화학식(V)의 4-메틸렌테트라하이드로푸란 화합물 및 화학식(IX)의 테트라하이드로피란 화합물의 제조방법에 관한 것이다. The present application relate to process for preparation of tetrahydrofuran compound of formula II, 4-Methylene tetrahydrofuran compound of formula V and tetrahydropyran compound of formula IX which are useful as intermediates for the preparation of halichondrin B analogues such as Eribulin or its pharmaceutically acceptable salts.