Compounds and compositions against visceral hypersensitivity

• Main Authors: VAN DER SAAG ANTONIE JOHANNES, POSSEMIERS SAM, STEVENS YALA, SALDEN BOUKE
• Format: Patent
• Language: English; Korean
• Published: 15.07.2019
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS

본 발명은 내장 과민증의 치료에 사용하기 위한, 헤스페리틴-7-루티노시드 2S와 같은 화학식 I의 화합물에 관한 것이다. 본 발명의 화합물 및 조성물은 과민성 장 증후군 또는 내장의 노인성 경도 전신 염증이 있으나, 경련성 장 수축은 없는 대상에서 내장 과민증의 치료에 특히 유용하다. The present invention relates to compounds of formula (I), such as hesperitin-7-rutinoside 2S, for use in the treatment of visceral hypersensitivity. Compounds and compositions of the invention are particularly useful in the treatment of visceral hypersensitivity in a subject having irritable bowel syndrome or age-associated low grade systemic inflammation of the gut, but lacking spasmodic intestinal contractions.