Intermediates of chiral piperidine derivatives and preparation method thereof

By a manufacturing method of the present invention, it is possible to manufacture tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate having optical activity at a high yield while having high purity and optical activity by a method capable of industrially mass production by using commercially availabl...

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Bibliographic Details
Main Authors CHOI KWANG DO, RYU CHAE YOUNG, KIM EUN SUN, HEO SEUNGPYEONG, KWEON JAE HONG, KO DONG HYUN, LEE HYUK WOO
Format Patent
LanguageEnglish
Korean
Published 19.06.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:By a manufacturing method of the present invention, it is possible to manufacture tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate having optical activity at a high yield while having high purity and optical activity by a method capable of industrially mass production by using commercially available reagents and solvents. In addition, by using a novel intermediate of the present invention, it is possible to manufacture tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate having optical activity in a high purity and the high yield. 본 발명의 제조방법을 통하여 광학활성을 갖는 터트-부틸 3-메틸-4-옥소피페리딘-1-카르복실레이트를 통상적으로 사용 가능한 시약과 용매를 사용하여, 산업적으로 대량생산이 가능한 방법으로 고순도의 광학활성을 가지면서 고수율로 제조할 수 있다. 또한, 본 발명의 신규 중간체를 통하여 광학활성을 갖는 터트-부틸 3-메틸-4-옥소피페리딘-1-카르복실레이트를 고순도 및 고수율로 제조할 수 있다.
Bibliography:Application Number: KR20170169227