SIGNAL AMPLIFICATION IN LATERAL FLOW AND RELATED IMMUNOASSAYS

• Main Authors: BLEILE DENNIS M, CUESICO CRISTINA, MEHRA RAJESH K, WALKER JEREMY, ARON KENNETH P
• Format: Patent
• Language: English; Korean
• Published: 09.05.2019
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

본 발명은, 시험 샘플 중의 항체의 검출을 향상시키는데 유용한 방법, 장치, 조성물(예를 들면, 포획 복합체), 및 키트를 제공한다. 당해 방법, 장치, 및 조성물은, 단백질 A, 단백질 G, 및/또는 Fc-특이적 항체와 같은 검출가능한 Fc-결합 분자를 이용하여 측방 유동 검정과 같은 면역검정에서 검출된 항체의 신호를 증폭시킨다. The present invention provides methods, devices, compositions (e.g., capture complexes), and kits useful for enhancing the detection of antibodies in a test sample. The methods, devices, and compositions utilize detectable Fc-binding molecules such as Protein A, Protein G, and/or an Fc-specific antibody to amplify the signal of a detected antibody in immunoassays, such as lateral flow assays.