TATκ-CDKL5 융합 단백질, 그의 조성물, 제형 및 용도

• Main Authors: CLARK SEAN, LACCONE FRANCO, CIANI ELISABETTA
• Format: Patent
• Language: Korean
• Published: 02.04.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

TATκ-CDKL5 융합 단백질을 함유하는 조성물 및 제형이 본 명세서에 개시된다. 또한, TATκ-CDKL5 cDNA를 함유하는 벡터로부터의 TATκ-CDKL5 융합 단백질의 생성 방법 및 TATκ-CDKL5 cDNA를 함유하는 벡터 및 TATκ-CDKL5 융합 단백질로의 세포의 형질도입 방법이 개시된다. 또한, 융합 단백질의 전신 또는 정맥내 투여에 의한 CDKL5 결핍의 치료를 위한 TATκ-CDKL5 융합 단백질의 용도가 개시된다. Disclosed herein are compositions and formulations containing a TATκ-CDKL5 fusion protein. Also disclosed are methods of producing a TATκ-CDKL5 fusion protein from vectors containing a TATκ-CDKL5 cDNA and methods of transducing cells with the vectors containing a TATκ-CDKL5 cDNA and the TATκ-CDKL5 fusion protein. Also disclosed are uses of TATκ-CDKL5 fusion proteins for treating CDKL5 deficiencies by systemic or intravenous administration of the fusion proteins.