레티노이드-관련 희귀 수용체 감마의 신규한 헤테로방향족 조절제

• Main Authors: JESSIMAN ALAN STUART, SØRENSEN MORTEN DAHL, JOHNSON PATRICK STEPHEN, MAANSSON KRISTOFFER
• Format: Patent
• Language: Korean
• Published: 13.03.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

본 발명은 하기 일반식 (I)에 따른 화합물에 관한 것이다:식 중, X는 N 또는 CH이고; R은 -CN, (C-C)알킬, (C-C)사이클로알킬, (3-7원)헤테로사이클로알킬, (5-6원)헤테로아릴, (C-C)사이클로알킬(C-C)알킬, (3-7원)헤테로사이클로알킬-(C-C)알킬 또는 (5-6원)헤테로아릴-(C-C)알킬이며; R는 할로겐, 사이아노, (C-C)알킬 또는 (C-C)사이클로알킬이고; R은 할로겐, 사이아노, (C-C)알킬, (C-C)할로알킬 또는 (C-C)사이클로알킬이고; R는 (C-C)알킬 또는 (C-C)할로알킬이며; R는 (C-C)알킬, (C-C)사이클로알킬, (C-C)알킬-(C-C)사이클로알킬, (C-C)사이클로알킬-(C-C)알킬, (3-7원)헤테로사이클로알킬, 페닐, (5-6원)헤테로아릴 또는 -OR이다. 본 발명은 또한 요법에 사용하기 위한 상기 화합물, 상기 화합물을 포함하는 약제학적 조성물 및 상기 화합물의 제조용의 중간체에 관한 것이다. wherein X represents N or CH; R1 is -CN, (C1-C6)alkyl, (C3-C7)cycloalkyl, (3-7 membered)heterocycloalkyl, (5-6 membered)heteroaryl, (C3-C7)cycloalkyl(C1-C4)alkyl, (3-7 membered)heterocycloalkyl-(C1-C4)alkyl or (5-6 membered)heteroaryl-(C1-C4)alkyl; R2 is halogen, cyano, (C1-C4)alkyl or (C3-C7)cycloalkyl; R3 is halogen, cyano, (C1-C4)alkyl, (C1-C4)haloalkyl or (C3-C7)cycloalkyl; R4 is (C1-C4)alkyl or (C1-C4)haloalkyl; R5 is (C1-C6)alkyl, (C3-C7)cycloalkyl, (C1-C6)alkyl-(C3-C7)cycloalkyl, (C3-C7)cycloalkyl-(C1-C6)alkyl, (3-7 membered)heterocycloalkyl, phenyl, (5-6 membered)heteroaryl or -ORa. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds and to intermediates for preparation of said compounds.