[1,2,4]트리아졸로[1,5-A]피리디닐 치환된 인돌 화합물

• Main Authors: HEGDE SUBRAMAYA, SHERWOOD TREVOR C, PASUNOORI LAXMAN, POSY SHOSHANA L, MACOR JOHN E, LOMBARDO LOUIS J, SISTLA RAMESH KUMAR, HAQUE TASIR SHAMSUL, MUSSARI CHRISTOPHER P, RATNA KUMAR SREEKANTHA, RAMACHANDRA ANUPAMA, DODD DHARMPAL S, DYCKMAN ALARIC J
• Format: Patent
• Language: Korean
• Published: 06.03.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

R, R, R, R, R, m, n, 및 p가 본원에 정의된 화학식 (I)의 화합물 또는 그의 염이 개시된다. 또한 톨-유사 수용체 7, 또는 8, 또는 9를 통한 신호전달의 억제제로서 이러한 화합물 및 이러한 화합물을 포함하는 제약 조성물을 사용하는 방법이 개시된다. 이들 화합물은 염증성 및 자가면역 질환을 치료하는 데 유용하다. Disclosed are compounds of Formula (I)or a salt thereof, wherein R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.