METHOD FOR DETERMINING AN ANALYTE CONCENTRATION

• Main Authors: HORN CARINA, UNKRIG VOLKER
• Format: Patent
• Language: English; Korean
• Published: 18.02.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; DIAGNOSIS; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; IDENTIFICATION; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; SURGERY; TESTING; VINEGAR; WINE

본 발명은 샘플 (110) 에서 적어도 하나의 분석물질의 적어도 하나의 농도를 결정하기 위한, 특히 체액의 샘플 (110) 에서 적어도 하나의 대사물질을 검출하기 위한 방법, 테스트 엘리먼트 (50), 및 디바이스 (190) 에 관한 것이며, 여기서 적어도 하나의 테스트 화학물질 (102) 을 갖는 적어도 하나의 테스트 엘리먼트 (50) 가 사용되고, 여기서 분석물질과 테스트 화학물질 (102) 의 적어도 하나의 반응이 검출된다. 본 발명은 또한 적어도 하나의 마커 (104, 104') 에 관한 것이며, 여기서 마커 (104, 104') 는 분석물질 (117) 과 상이하고, 여기서 샘플 (110) 에서 또는 샘플 (110) 의 적어도 하나의 컴포넌트에서 마커 (104, 104') 의 적어도 하나의 확산이 검출된다. 적어도 하나의 보정 정보의 피스가 마커 (104, 104') 의 확산으로부터 생성되고, 여기서 분석물질의 농도는 보정 정보를 고려하면서 분석물질과 테스트 화학물질 (102) 의 반응으로부터 결정된다. Determining at least one concentration of at least one analyte in a sample (110), preferably at least one metabolite in a sample of a body fluid, comprises e.g.: using at least one test element (50) with at least one test chemical (102) and determining at least one reaction of the test chemical with the analyte; further using at least one marker (104) that is different from the analyte and determining at least one diffusion of the marker in the sample or at least one portion of the sample; and determining the concentration of the analyte from the reaction of the test chemical with the analyte. Determining at least one concentration of at least one analyte in a sample (110), preferably at least one metabolite in a sample of a body fluid, comprises using at least one test element (50) with at least one test chemical (102), determining at least one reaction of the test chemical with the analyte, further using at least one marker (104) that is different from the analyte, determining at least one diffusion of the marker in the sample or at least one portion of the sample, generating at least one correction information from the diffusion of the marker, and determining the concentration of the analyte from the reaction of the test chemical with the analyte considering the correction information. Independent claims are also included for: (1) test element useful in the above method, comprising (i) at least one test chemical to carry out at least one detectable reaction with the analyte, (ii) at least one marker in at least one first area of the test element, to diffuse at least partially from the first region of the test element into at least one second region; and (2) an apparatus for the above method, comprising (a) at least one test element with at least one test chemical, and (b) at least one marker, where the apparatus is adapted for determining at least one reaction of the test chemical with the analyte, determining at least one diffusion of the marker in the sample or at least one portion of the sample, generating at least one correction information from the diffusion of the marker, and determining the concentration of the analyte from the reaction of the test chemical with the analyte considering the correction information.