PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING VASCULAR DISEASES COMPRISING MESENCHYMAL STEM CELL EXPRESSING HEPATOCYTE GROWTH FACTOR

• Main Authors: PARK HUN JUN, JUNG SOO HYUN, PARK BONG WOO, KIM HEY YON, JANG JINAH, DAS SANSKRITA, LEE SOON MIN, CHO DONG WOO, KIM SEOK WON
• Format: Patent
• Language: English; Korean
• Published: 13.02.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The present invention relates to a pharmaceutical composition for preventing or treating vascular diseases containing a mesenchymal stem cell expressing a hepatocyte growth factor (HGF) protein as an active component. The pharmaceutical composition for preventing or treating vascular diseases containing the mesenchymal stem cell expressing the HGF protein as the active component expresses HGF to induce vascularization, thereby stimulating the formation of capillaries and enhancing cardiac function. Therefore, the pharmaceutical composition according to the present invention can be usefully applied as the pharmaceutical composition for preventing or treating vascular diseases, particularly cardiovascular diseases. 본 발명은 간세포성장인자(HGF) 단백질을 발현하는 중간엽줄기세포를 유효성분으로 포함하는 혈관계 질환 예방 또는 치료용 약학 조성물에 관한 것이다. 본 발명의 HGF 단백질을 발현하는 중간엽줄기세포를 유효성분으로 포함하는 혈관계 질환 예방 또는 치료용 약학 조성물은 HGF를 발현하여 혈관신생을 유도함으로써 모세혈관의 형성을 촉진시키고 심기능을 향상시킨다. 따라서, 본 발명의 약학 조성물은 혈관계 질환, 특히 심혈관계 질환의 예방 또는 치료용 약학 조성물로 유용하게 활용될 수 있다.