VEGF-Grab A conjugate of VEGF-Grab protein and a drug and use thereof

• Main Authors: KIM, HO MIN, LEE, DAE HEE, HONG, HYO JEONG
• Format: Patent
• Language: English; Korean
• Published: 10.01.2019
• Subjects: CHEMISTRY; FODDER; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The present invention relates to a VEGF-Grab protein-drug conjugate and a use thereof and, more particularly, to a conjugate of a fusion protein in which a VEGFR1 domain 2, a VEGFR1 domain 3, and an antibody fragment are connected and a drug, a pharmaceutical composition for prevention or treatment of cancer or angiogenesis-related disease, comprising the conjugate, and a method for prevention or treatment of cancer or angiogenesis-related disease. Serving as a multi-paratopic VEGF decoy receptor, the conjugate including a VEGF-Grab protein and a drug of the present invention can be used as a multi-purpose platform for treatment of cancer or angiogenesis-related disease. 본 발명은 VEGF-Grab 단백질과 약물의 결합체 및 이의 용도에 관한 것으로, 구체적으로 VEGFR1 도메인 2, VEGFR1 도메인 3 및 항체 단편이 연결된 융합단백질과 약물의 결합체, 상기 결합체를 포함하는 암 또는 혈관신생 관련 질환의 예방 또는 치료용 약학 조성물 및 암 또는 혈관신생 관련 질환의 예방 또는 치료 방법에 관한 것이다. 본 발명의 VEGF-Grab 단백질과 약물을 포함하는 결합체는 다중-파라토프 VEGF 디코이 수용체로서, 암 또는 혈관신생 관련 질환 치료를 위한 다목적성 플랫폼으로 사용할 수 있다.