Composition for preventing improving or treating of fibrosis

• Main Authors: RHO MUN CHUAL, LEE SEUNG WOONG, LEE SEUNG JAE, KIM HAK RYUL, JUNG KYUNG SOOK, LEE SO YOUNG
• Format: Patent
• Language: English; Korean
• Published: 09.01.2019
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The present invention relates to a composition comprising a Phaseolus angularis extract, a fraction thereof or oleanolin acid acetate isolated therefrom as an active ingredient. The composition has an effect of inhibiting epithelial-mesenchymal transition, increasing pulmonary volume reduced by pulmonary fibrosis, and ameliorating liver fibrosis and oxidative stress, and thus can be useful for preventing, ameliorating, or treating fibrosis. 본 발명은 적소두 추출물, 이의 분획물 또는 이로부터 분리한 올레아놀린산 아세테이트를 유효성분으로 포함하는 조성물에 관한 것으로, 상기 조성물은 상피-간엽 이행을 억제하고, 폐섬유화에 의하여 감소된 폐용적을 증가시키며, 간섬유화 및 산화적 스트레스를 개선하는 효능이 있으므로 섬유화증의 예방, 개선 또는 치료 용도로 유용하게 이용될 수 있다.