TGase 2 -58- Quinoline-58-dione derivatives for TGase inhibitor and the pharmaceutical composition comprising the same

• Main Authors: KO EUN BI, WOO SEO YEON, KIM SOONG HYUN, LEE EUNHYE, KIM SOO YOUL, SONG MINSOO, PARK GA YOUNG, IM CHUN YOUNG, HWANG HEE JONG
• Format: Patent
• Language: English; Korean
• Published: 01.10.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to a quinolin-5,8-dione derivative compound represented by chemical formula I, an optical isomer thereof or a pharmaceutically acceptable salt thereof. The compound represented by chemical formula I of the present invention has a TGase 2 inhibitory effect, and the pharmaceutical composition comprising the same is useful for preventing or treating disorders or diseases mediated by TGase 2 or response to TGase 2 inhibition. In chemical formula I, R_1 is hydrogen, halogen, -C_1-6 alkyl or -O-C_1-6 alkyl. 본 발명은 화학식 I로 표시되는 퀴놀린-5,8-디온 유도체 화합물, 이의 광학이성질체 또는 약제학적으로 허용되는 이의 염에 대한 것이다. 본 발명의 화학식 I로 표시되는 화합물은, TGase 2 저해 효과를 갖고, 이를 포함하는 약제학적 조성물은 TGase 2에 의해 매개되거나 TGase 2의 억제에 대해 반응하는 장애 또는 질환의 예방 또는 치료에 유용하게 사용될 수 있다.