아미노아졸 유도체

• Main Authors: HOSODA SHINNOSUKE, TAKAGI KENICHIRO, YOKOYAMA EMI, UNOKI GEN, SASAKI KOSUKE, SHIBATA JUN, WATANABE HIDEKAZU, HORIE KYOHEI
• Format: Patent
• Language: Korean
• Published: 03.08.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

하기 식으로 나타내는, 안드로겐 수용체의 활성 조절 작용을 갖는 화합물 또는 그 의약상 허용되는 염. X 는 S, O 를, Z 는 (R)-A-(CRR)-(CRR)- 를, A 는 아릴, 헤테로아릴을, R은 알킬, 시클로알킬, 알케닐, 알키닐, 알콕시알킬, 아릴, 아릴알킬, 복소 고리, 복소 고리 알킬을, R는, 수소, 할로겐, 알킬, 시클로알킬, 페닐을, R은, 수소, 할로겐, 알킬, 시클로알킬, 알콕시알킬, 알케닐, 알키닐, 시클로알케닐, 아릴, 아릴알킬, 복소 고리, 복소 고리 알킬, 아실, 시클로알킬카르보닐, 벤조일, 스피로알킬, 아다만틸, 실릴, RRNCO- 를, R, R는 수소, 할로겐, 알킬, 페닐, 시클로알킬을 나타낸다. A compound, represented by the following formula or a medically acceptable salt thereof, having an effect of regulating the activity of an androgen receptor. In the formula, X represents S, O; Z represents (R a ) n -A-(CR 13 R 14 ) 0-1 -(CR 11 R 12 ) 0-1 -; A represents aryl, heteroaryl; R 1 represents alkyl, cycloalkyl, alkenyl, alkynyl, alkoxyalkyl, aryl, arylalkyl, heterocycle, heterocyclic alkyl; R 2 represents hydrogen, halogen, alkyl, cycloalkyl, phenyl; R3 represents hydrogen, halogen, alkyl, cycloalkyl, alkoxyalkyl, alkenyl, alkynyl, cycloalkenyl, aryl, arylalkyl, heterocycle, heterocyclic alkyl, acyl, cycloalkylcarbonyl, benzoyl, spiroalkyl, adamantyl, silyl, R 31 R 32 NCO-; R 4 and R 5 represent hydrogen, halogen, alkyl, phenyl, and cycloalkyl.