위장관 염증 질환의 치료를 위한 JAK 저해제 화합물의 프로드러그

• Main Authors: LONG DANIEL D, HUDSON RYAN, BRASSIL PATRICK J, LOO MANDY, WILTON DONNA A.A
• Format: Patent
• Language: Korean
• Published: 11.07.2018
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; DERIVATIVES THEREOF; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; SUGARS; VINEGAR; WINE

본 발명은 JAK 저해제의 포유동물의 위장관으로의 표적화된 전달을 위한 JAK 저해제의 프로드러그인 화학식 (I)의 화합물을 제공한다. 본 발명은 또한 상기 화합물을 포함하는 약학적 조성물, 위장관 염증 질환을 치료하기 위해 상기 화합물을 사용하는 방법, 및 상기 화합물을 제조하는데 유용한 방법 및 중간체를 제공한다:. The invention provides compounds which are prodrugs of a JAK inhibitor agent for the targeted delivery of the JAK inhibitor to the gastrointestinal tract of a mammal. The invention also provides pharmaceutical compositions comprising the compounds, methods of using the compounds to treat gastrointestinal inflammatory diseases, and processes and intermediates useful for preparing the compounds.