Composition comprising an extract from sea cucumber for preventing and treating Bruch's membrane malfunction-related disease

• Main Authors: KIM DAE BONG, HUSSAIN ALI, LEE YUNHEE
• Format: Patent
• Language: English; Korean
• Published: 27.06.2018
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The present invention relates to a composition for preventing and treating Bruch′s membrane dysfunction-related diseases, comprising a sea cucumber extract as an effective ingredient, and more specifically, to a composition for preventing and treating Bruch′s membrane dysfunction-related diseases, comprising a sea cucumber extract or fraction which has effects of regenerating a Bruch′s membrane of eyes of a patient and improving a transport function thereof. The composition according to the present invention is capable of delaying or reversing senescence of eyes by improving a transport function of a Bruch′s membrane and promoting regeneration of the Bruch′s membrane, and thus has excellent effects of preventing and treating diseases attributed to senescence-associated Bruch′s membrane dysfunction, such as age-related macular degeneration (AMD), Sorsby′s fundus dystrophy, Malattia Levintanese (ML), Stargardt disease, Best′s vitelliform retinal dystrophy or Doyne′s honeycomb retinal dystrophy (DHRD). 본 발명은 해삼 추출물을 유효성분으로 하는 브루크막 기능 저하 관련 질병 예방 및 치료용 조성물에 관한 것으로서, 보다 구체적으로는 눈의 브루크막을 재생시키고, 수송기능을 개선시키는 효과를 갖는 해삼 추출물 또는 분획물을 포함하는 브루크막 기능 저하와 관련된 질병의 예방 및 치료용 조성물 관한 것이다. 본 발명에 따른 조성물은 브루크막의 수송 기능을 개선시키고, 브루크막의 재생을 촉진시킴으로써 눈의 노화 과정을 늦추거나 되돌리는 효과가 있어, 노화에 따른 브루크막의 기능 저하로 인하여 발생하는 나이 관련 황반 변성(AMD), 소르스비 안저 이영양증(Sorsby's fundus dystrophy), ML(Malattia Levintanese), 스타가트병 (Stargardt disease), 베스트 노른자 모양 황반 이영양증(Best's vitelliform retinal dystrophy) 또는 DHRD(Doyne's honeycomb retinal dystrophy) 와 같은 질병의 예방 및 치료가 뛰어나다.