Anti-inflammatory Composition Using an Extract of Black Radish

• Main Authors: HONG, SEUNG HYUN, JIN, HYUE JU, KIM, GI OK, LEE, YONG BUM, SONG, SANG MOK, YANG, DA WUN, LEE, HAK SUNG, LEE, SEUNG MUK, OH, DONG KWAN, KO, CHANG SIK, KIM, SEONG EUN, YOON, SEON A, KIM, HYUN KYU
• Format: Patent
• Language: English; Korean
• Published: 04.05.2018
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

Disclosed in the present invention is an anti-inflammatory composition using a black radish extract. The black radish extract inhibited secretion or production of NO, inflammatory cytokines (TNF-α, IL-6, and IL-1β), PGE2, COX-2, and iNOS in a lipopolysaccharide (LPS)-stimulated murine macrophage cell line (RAW 264.7 cells), and reduced phosphorylation of STAT3. In addition, the black radish extract reduces phosphorylation of JAK2 and STAT3 in an IL-6-stimulated murine macrophage cell line (RAW 264.7 cells). Accordingly, the black radish extract of the present invention may be beneficially used as a composition for preventing and treating inflammatory diseases including rheumatoid arthritis and dermatitis by inhibiting IL-6, JAK2, and STAT3 signal transduction mechanisms. 본 발명은 흑무 추출물을 이용한 항염증용 조성물을 개시한다. 상기 흑무 추출물는 LPS(lipopolysacharide)로 자극된 마우스 대식세포주(RAW 264.7 cells)에서 NO, 염증성 사이토카인(TNF-α, IL-6, IL-1β), PGE2, COX-2 및 iNOS의 분비 또는 생성을 억제하였으며 STAT3의 인산화를 감소시켰다. 또한 IL-6 로 자극된 마우스 대식세포주(RAW 264.7 cells)에서 JAK2, STAT3의 인산화를 감소시켰다. 따라서 본 발명의 흑무 추출물은 IL-6, JAK2, STAT3 신호전달기작을 억제하여 류마티스 관절염, 피부염 등을 비롯한 염증성 질환의 예방 및 치료 조성물로 유용하게 이용될 수 있다.