PARP 억제제로서의 헤테로아릴 유도체

• Main Authors: KAMBOJ RAJENDER KUMAR, TILEKAR AJAY RAMCHANDRA, GUPTA NISHANT RAMNIWASJI, PALLE VENKATA P, SINHA NEELIMA, KURHADE SANJAY PRALHAD, KARCHE NAVNATH POPAT, JADHAV GANESH RAJARAM
• Format: Patent
• Language: Korean
• Published: 11.04.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

본원에는, 화학식(I)의 화합물, 이의 토토머형, 이의 입체이성체 및 이의 약학적으로 허용가능한 염; 화합물, 이의 토토머, 입체이성체 또는 염을 포함하는 약학적 조성물; 및 대상체의 PARP 효소를 억제함으로써 치료 또는 예방되는 질환 또는 장애, 예컨대, 암의 치료 또는 예방 방법이 개시된다:상기 식에서, 고리 Ar, 고리 B, R-R, X, Y, p, q, r 및 s는 본 명세서에 정의된 바와 같다. Disclosed are compounds of formula (I), their tautomeric forms, stereoisomers, and pharmaceutically acceptable salts thereof, wherein ring Ar, ring B, R1-R5, X, Y, p, q, r, and s are as defined in the specification, pharmaceutical compositions including a compound, tautomer, stereoisomer, or salt thereof, and methods of treating or preventing diseases or disorders, for example, cancer, that are amenable to treatment or prevention by inhibiting the PARP enzyme of a subject.