Composition comprising the extract of Rosa rugosa Thunb for preventing or treating liver disease

• Main Authors: PARK SANG MI, PARK SOOK JAHR, CHO IL JE, SAE KWANG KU, KIM YOUNG WOO, KIM SANG CHAN, JUNG JI YUN
• Format: Patent
• Language: English; Korean
• Published: 28.03.2018
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The present invention relates to a composition containing an extract of Rosa rugosa Thunb. for preventing or treating a liver disease. The composition of the present invention can be used as an active ingredient of health functional foods for a liver disease medicine or liver disease prevention by checking that an extract of Rosa rugosa Thunb. has an excellent effect of suppressing phosphorylation of an Smad molecule by a transforming growth factor-beta 1 (TGF-β1), and is not toxic to a normal cell. 본 발명은 매괴화 추출물을 유효성분으로 함유하는 간질환의 예방 또는 치료용 조성물에 관한 것으로, 본 발명의 매괴화 추출물은 간세포 손상 시 증가하는 형질전환성장인자 베타1(TGF-β1)에 의한 Smad 분자의 인산화를 억제하는 효과가 우수하고 정상 세포에 독성을 유발하지 않는다는 것을 확인함으로써, 간질환 치료제 또는 간질환 예방을 위한 건강기능성 식품의 유효성분으로 사용할 수 있다.