STING 효능제로서 시클릭 디-뉴클레오티드 화합물

• Main Authors: CUMMING JARED N, JEWELL JAMES P, TRUONG QUANG T, ALTMAN MICHAEL D, LIM JONGWON, HENDERSON TIMOTHY J, WALSH SHAWN P, LU MIN, CHANG WONSUK, LIANG RUI, CHILDERS MATTHEW LLOYD, LIU HONG, OTTE RYAN D, SIU TONY, ANDRESEN BRIAN, HAIDLE ANDREW MARC, NORTHRUP ALAN B, ZHAO KAKE, TROTTER BENJAMIN WESLEY
• Format: Patent
• Language: Korean
• Published: 26.03.2018
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SUGARS

제I형 인터페론 생산의 유도제, 특히 STING 활성제로서 유용할 수 있는, 염기, 염기, Y, Y, X, X, X, X, X, X, X, X, R, R, R, R, R, R, R, R, R, R, R, R, R, 및 R가 본원에 정의되어 있는 화학식 (I), 화학식 (I'), 또는 화학식 (I")의 폴리시클릭 화합물 부류가 제공된다. 또한, 화합물의 합성 방법 및 용도가 제공된다. A class of polycyclic compounds of general formula (I), of general formula (I'), or of general formula (I"), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.