7H-피롤로[2,3-d]피리미딘 유도체의 제조 방법 및 그의 중간체

• Main Authors: HARA KATSUYOSHI, MANTA NAOKI, HARA YOSHINORI, YAMASAKI TAKAHIRO, MURAKAMI KENGO, SAKAI TAKAYUKI
• Format: Patent
• Language: Korean
• Published: 09.03.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

본 발명은, 야누스 키나아제(JAK) 저해제로서 유용한 7H-피롤로[2,3-d]피리미딘 유도체의 제조 방법, 그의 중간체 및 그의 중간체의 제조 방법을 제공한다. 본 발명은, (3S,4R)-3-메틸-1,6-디아자스피로[3.4]옥탄-1-카르복실산벤질의 유기산과의 염을 사용한 3-[(3S,4R)-3-메틸-6-(7H-피롤로[2,3-d]피리미딘-4-일)-1,6-디아자스피로[3.4]옥탄-1-일]-3-옥소프로판니트릴의 제조 방법을 제공한다. The present invention provides a method for producing a 7H-pyrrolo[2,3-d]pyrimidine derivative that is useful as a janus kinase (JAK) inhibitor; an intermediate of the 7H-pyrrolo[2,3-d]pyrimidine derivative; and a method for producing the intermediate. The present invention provides a method for producing 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile, which uses a salt of an organic acid and (3S,4R)-3-methyl-1,6-diazaspiro[3.4]octane-1-carboxylic acid benzyl.