에피머라제 및 벤질아이소퀴놀린 알칼로이드를 제조하는 방법

• Main Authors: LI YANRAN, GALANIE STEPHANIE, THODEY CATHERINE, SMOLKE CHRISTINA D, TRENCHARD ISIS
• Format: Patent
• Language: Korean
• Published: 14.02.2018
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

()-1-벤질아이소퀴놀린 알칼로이드로 ()-1-벤질아이소퀴놀린 알칼로이드를 에피머화하는 방법이 제공된다. 상기 방법은 ()-1-벤질아이소퀴놀린 알칼로이드를 적어도 하나의 효소와 접촉시키는 단계를 포함한다. ()-1-벤질아이소퀴놀린 알칼로이드를 적어도 하나의 효소와 접촉시키는 단계는 ()-1-벤질아이소퀴놀린 알칼로이드로 ()-1-벤질아이소퀴놀린 알칼로이드를 전환시킨다. A method of epimerizing an (S)-1-benzylisoquinoline alkaloid to an (R)-1-benzylisoquinoline alkaloid is provided. The method comprises contacting the (S)-1-benzylisoquinoline alkaloid with at least one enzyme. Contacting the (S)-1-benzylisoquinoline alkaloid with the at least one enzyme converts the (S)-1-benzylisoquinoline alkaloid to an (R)-1-benzylisoquinoline alkaloid.