Crystalline Polymorphs of Varenicline Free Base Method for Preparing or Use Thereof

The present invention relates to a crystalline polymorphic form 3 of varenicline free base, a preparation method thereof and uses thereof. The crystalline polymorphic form 3 of varenicline free base has excellent thermodynamic stability and has physicochemical properties suitable for preparing formu...

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Main Authors JOUNG, JUNG GUN, YOUN, WON NO, KIM, DAE SUNG, LEE, JONG KWON, KIM, JAE SUN, KIM, MIN JI, AN, JI HUN, BAEK, SUNG HYUN, JUNG, JU YOUNG, JUNG, KI WON, PARK, DONG HYEON, RYU, HYUNG CHUL, JEONG, HYEON GUN, SEO, HO KYUNG
Format Patent
LanguageEnglish
Korean
Published 29.12.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to a crystalline polymorphic form 3 of varenicline free base, a preparation method thereof and uses thereof. The crystalline polymorphic form 3 of varenicline free base has excellent thermodynamic stability and has physicochemical properties suitable for preparing formulations. The crystalline polymorphic form 3 of varenicline free base can be used for treating nicotine dependence, indulgence, abstinence disorder or symptoms so a composition of the present invention can be prescribed for prohibiting smoking. 본 발명은 바레니클린 유리염기의 결정질 다형체 3형, 이의 제조방법 및 이의 용도에 관한 것이다. 본 발명의 바레니클린 유리염기의 결정질 다형체 3형은 열역학적 안정성이 우수하고 제형 제조에 적합한 물리화학적 특성을 갖는다. 본 발명의 바레니클린 유리염기의 결정질 다형체 3형은 니코틴 의존, 탐닉 또는 금단 장애 또는 상태의 치료 용도로 이용될 수 있어, 본 발명의 조성물은 금연을 위한 용도로 처방되어질 수 있다.
Bibliography:Application Number: KR20160076846