면역조정제

• Main Authors: MULL ERIC, LI LING, SUN LI-QIANG, SCOLA PAUL MICHAEL, MILLER MICHAEL MATTHEW, POIRIER MAUDE A, GILLIS ERIC P, ZHAO QIAN, MAPELLI CLAUDIO, ALLEN MARTIN PATRICK
• Format: Patent
• Language: Korean
• Published: 29.09.2017
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

본 개시내용은 PD-1/PD-L1 및 PD-L1/CD80 단백질/ 단백질 상호작용을 억제하며, 따라서 암 및 감염성 질환을 포함한 다양한 질환의 호전에 유용한 신규 마크로시클릭 펩티드를 제공한다. The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseas...