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본 개시내용은 PD-1/PD-L1 및 PD-L1/CD80 단백질/ 단백질 상호작용을 억제하며, 따라서 암 및 감염성 질환을 포함한 다양한 질환의 호전에 유용한 신규 마크로시클릭 펩티드를 제공한다. The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseas...

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Bibliographic Details
Main Authors MULL ERIC, LI LING, SUN LI-QIANG, SCOLA PAUL MICHAEL, MILLER MICHAEL MATTHEW, POIRIER MAUDE A, GILLIS ERIC P, ZHAO QIAN, MAPELLI CLAUDIO, ALLEN MARTIN PATRICK
Format Patent
LanguageKorean
Published 29.09.2017
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:본 개시내용은 PD-1/PD-L1 및 PD-L1/CD80 단백질/ 단백질 상호작용을 억제하며, 따라서 암 및 감염성 질환을 포함한 다양한 질환의 호전에 유용한 신규 마크로시클릭 펩티드를 제공한다. The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
Bibliography:Application Number: KR20177024283