USE OF MICROVESICLES IN DIAGNOSIS PROGNOSIS AND TREATMENT OF MEDICAL DISEASES AND CONDITIONS

• Main Authors: SKOG JOHAN KARL OLOV, BROWN DENNIS, BREAKEFIELD XANDRA O, RUSSO LEILEATA M, MIRANDA KEVIN C
• Format: Patent
• Language: English; Korean
• Published: 06.09.2017
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

본 개시 내용은 대상체로부터의 생물학적 샘플로부터 단리된 미세소포체 중의 생체마커를 검출하여 대상체에서 질환 또는 다른 의학적 병태를 진단, 예후, 모니터링 및 평가하는 것을 보조하는 방법에 관한 것이다. 또한, 본 개시 내용은 생물학적 샘플 내의 미세소포체의 농도를 측정하여 질환을 진단, 모니터링하는 방법; 핵산 또는 단백질을 함유하는 미세소포체를 투여함으로써 표적 모두에게 상기 핵산 또는 단백질을 전달하는 방법; 미세소포체 무함유 또는 미세소포체가 강화된 체액 분획을 환자 내로 도입하여 체액 주입을 실시하는 방법에 관한 것이다. A method is provided for aiding in the diagnosis, prognosis, monitoring of disease progression, analysis of disease recurrence, and/or monitoring treatment effectiveness of a disease or other medical condition in a subject, the method comprising the steps of detecting nucleic acids or proteins within a microvesicle fraction of a biological sample from the subject, and analyzing the nucleic acids or proteins within the microvesicle fraction for the presence or absence of a nucleic acid biomarker, wherein the disease is a neoplastic disease.