N-Boc ETHYL N-BOC PIPERIDINYL PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS

• Main Authors: MOLINARI DANIELLE, SCOTT MARK E, KATTAR SAM, FU JIAMIN, ZHENG ZHIXIANG, FULLER PETER, DINSMORE CHRISTOPHER, KONG NORMAN, LIU YUMEI, BAI YUNFENG, GUERIN DAVID
• Format: Patent
• Language: English; Korean
• Published: 19.06.2017
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

본 발명은 JAK 억제제인 화학식 I의 화합물을 제공하며, 이와 같이 JAK-매개 질환 예컨대 류마티스 관절염, 천식, COPD 및 암의 치료에 유용하다. 본 발명은 JAK 억제제인 신규 화합물을 제공한다. 본 발명은 상기 신규 화합물을 사용하는 JAK-매개 질환 및 장애의 치료 및 예방 방법, 뿐만 아니라 상기 화합물을 함유하는 제약 조성물을 또한 제공한다. <화학식 I> The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer. The present invention provides novel compounds which are inhibitors of JAKs. The invention also provides a method for the treatment and prevention of JAK-mediated diseases and disorders using the novel compounds, as well as pharmaceutical compositions containing the compounds.