VL VHH HIGH AFFINITY AND AGGREGATIVELY STABLE ANTIBODIES ON THE BASIS OF VARIABLE DOMAINS VL AND A DERIVATIVE VHH

• Main Authors: SOLOVIEV VALERIY VLADIMIROVICH, EKIMOVA VICTORIA MIKHAILOVNA, MOROZOV DMITRIY VALENTINOVICH, GONCHAROVA OLGA VLADIMIROVNA, KORZHAVIN DMITRIY VALERIEVICH, CHERNOVSKAYA TATYANA VENIAMINOVNA, IVANOV ROMAN ALEXEEVICH, NEMANKIN TIMOFEY ALEKSANDROVICH, EVDOKIMOV STANISLAV RUDOLFOVICH, ULITIN ANDREY BORISOVICH, USTYUGOV YAKOV YUREVICH, SOFRONOVA EKATERINA VLADIMIROVNA, CHERNYH YULIA SERGEEVNA
• Format: Patent
• Language: English; Korean
• Published: 08.06.2017
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

제안하는 것은 경쇄의 가변 도메인 V과 유도체 VHH를 조합한 형태인, 가변 도메인을 함유하는 IgG 유형의 단일클론 항체이다. 이러한 항체는 위치 44 및/또는 45(카벳 넘버링 방식에 따름), 또는 이의 조합에 아미노산 치환을 함유할 수 있다. 기술된 항체는 친화성 증가 및 응집 안정성 향상을 나타낸다. The monoclonal IgG-type antibodies comprising variable domains represented by a combination of VHH-derivative with a variable domain of the light chain V L are offered. The said antibodies can comprise amino acid substitutions at positions 44 and 45 (Kabat numbering) or combinations thereof. Antibodies of the invention possess increased affinity and improved aggregation stability.