Biomarkers for predicting heart damage caused by radiation exposure and a diagnosing method thereof

• Main Authors: KIM, A RAM, BAE, SANG WOO, LEE, HAE JUNE, NAM, JAE KYUNG, LEE, YOON JIN
• Format: Patent
• Language: English; Korean
• Published: 25.05.2017
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; TESTING; VINEGAR; WINE

The present invention includes: a biomarker for the prediction of heart damage by radiation exposure, which includes an amino acid of a rank number 1 to increase manifestation in an endothelial cell of a heart blood vessel more than a normal person; a pharmacy composite for the prediction of heart damage to detect the biomarker and a kit including the composite; a method detecting the biomarker to provide necessary information for the prediction of heart damage by radiation exposure; a pharmacy composite for the prevention of heart damage by radiation exposure, including a manifestation suppressor or activation suppressor for the biomarker; and a method to screen candidate medical substances for the prevention of heart damage by radiation exposure by sorting a test substance to suppress the manifestation or activation of the biomarker. 본 발명은 정상인에 비해 심장혈관내피세포에서 발현이 증가하는 것으로서, 서열번호 1의 아미노산 서열을 갖는 L1CAM을 포함하는 방사선 피폭에 의한 심장 손상 예측용 바이오마커; 상기 바이오 마커를 검출하기 위한 심장 손상 예측용 약학 조성물 및 그 조성물을 포함하는 키트; 방사선 피폭에 의한 심장 손상 예측에 필요한 정보를 제공하기 위하여 상기 바이오마커를 검출하는 방법; 상기 바이오마커의 발현 억제제 또는 활성 억제제를 포함하는 방사선 피폭에 의한 심장 손상을 예방용 약학 조성물; 및 상기 바이오마커의 발현 또는 활성을 억제하는 피검물질을 선별함으로써 방사선 피폭에 의한 심장 손상을 예방용 의약의 후보물질을 스크리닝하는 방법을 제공한다.