1234-[]-3- SUBSTITUTED 1234- TETRAHYDROCYCLOPENTA[]INDOL-3-YL ACETIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS

• Main Authors: MOODY JEANNE V, ZHU XIUWEN, JONES ROBERT M, ULLMAN BRETT, BUZARD DANIEL J, HAN, SANG DON, LEHMANN JUERG, STIRN SCOTT, KIM, SUN HEE
• Format: Patent
• Language: English; Korean
• Published: 25.04.2017
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

본 발명은, 예를 들어 S1P1 수용체의 효능제로서의 유용한 약리학적 특성을 보이는, 특정 화학식 Ia의 치환된 1,2,3,4-테트라히드로시클로펜타[b]인돌-3-일)아세트산 유도체 및 이의 제약상 허용되는 염에 관한 것이다. <화학식 Ia>또한, 본 발명의 화합물을 함유하는 제약 조성물, 및 본 발명의 화합물 및 조성물을 S1P1 수용체-연관 장애, 예를 들어 건선, 류마티스성 관절염, 크론병, 이식 거부반응, 다발성 경화증, 전신 홍반성 루푸스, 궤양성 대장염, 제I형 당뇨병, 여드름, 미생물성 감염 또는 질환 및 바이러스성 감염 또는 질환의 치료에 사용하는 방법이 본 발명에 의해 제공된다. The present invention relates to certain substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives of Formula (Ia) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor.Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of S1P1 receptor-associated disorders, for example, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type I diabetes, acne, microbial infections or diseases and viral infections or diseases.