RORC2 - - METHYL- AND TRIFLUOROMETHYL-SUBSTITUTED PYRROLOPYRIDINE MODULATORS OF RORC2 AND METHODS OF USE THEREOF

본 발명은 메틸- 및 트라이플루오로메틸-치환된 피롤로피리딘, 이의 약학 조성물, 대상체에서 RORγ 활성을 조절하고/하거나 IL-17의 양을 감소시키는 방법, 및 상기 피롤로피리딘 및 이의 약학 조성물을 사용하여 다양한 질병을 치료하는 방법을 제공한다. The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activ...

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Main Authors ZAMARATSKI EDOUARD, JONES PETER, WENNERSTAL GORAN MATTIAS, MENTE SCOT RICHARD, KAILA NEELU, ZHANG LIYING, TRZUPEK JOHN DAVID, VAZQUEZ MICHAEL L, SCHNUTE MARK EDWARD, FLICK ANDREW CHRISTOPHER, XING LI
Format Patent
LanguageEnglish
Korean
Published 25.04.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:본 발명은 메틸- 및 트라이플루오로메틸-치환된 피롤로피리딘, 이의 약학 조성물, 대상체에서 RORγ 활성을 조절하고/하거나 IL-17의 양을 감소시키는 방법, 및 상기 피롤로피리딘 및 이의 약학 조성물을 사용하여 다양한 질병을 치료하는 방법을 제공한다. The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.
Bibliography:Application Number: KR20177007993