2S3S- 7--2-4--3-1--1H-124--5--4--1234--5- COFORMER SALTS OF 2S3S-METHYL 7-FLUORO-2-4-FLUOROPHENYL-3-1-METHYL-1H-124-TRIAZOL-5-YL-4-OXO-1234-TETRAHYDROQUINOLINE-5-CARBOXYLATE AND METHODS OF PREPARING THEM

본 발명은, 결정체 형태 등의, 선택적으로는 용매화물로서, 더 선택적으로는 수화물로서, (2,3)-메틸 7-플루오로-2-(4-플루오로페닐)-3-(1-메틸-1-1,2,4-트리아졸-5-일)-4-옥소-1,2,3,4-테트라하이드로퀴놀린-5-카르복실레이트의 공형성체 염, 및 (2,3)-메틸 7-플루오로-2-(4-플루오로페닐)-3-(1-메틸-1-1,2,4-트리아졸-5-일)-4-옥소-1,2,3,4-테트라하이드로퀴놀린-5-카르복실레이트의 선택적으로 공형성체 염으로서의 제조 방법에 관한 것이다. Described herein are coformer...

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Bibliographic Details
Main Authors CAMPBELL COLM, HERZ CHRISTIAN KLAUS, HENDERSON MARK, JAGUSCH CARSTEN, BAUER NICO, BONNAUD THIERRY, LAMBERT OLIVIER
Format Patent
LanguageEnglish
Korean
Published 07.04.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:본 발명은, 결정체 형태 등의, 선택적으로는 용매화물로서, 더 선택적으로는 수화물로서, (2,3)-메틸 7-플루오로-2-(4-플루오로페닐)-3-(1-메틸-1-1,2,4-트리아졸-5-일)-4-옥소-1,2,3,4-테트라하이드로퀴놀린-5-카르복실레이트의 공형성체 염, 및 (2,3)-메틸 7-플루오로-2-(4-플루오로페닐)-3-(1-메틸-1-1,2,4-트리아졸-5-일)-4-옥소-1,2,3,4-테트라하이드로퀴놀린-5-카르복실레이트의 선택적으로 공형성체 염으로서의 제조 방법에 관한 것이다. Described herein are coformer salts of (2S,3S)-methyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1H-1,2,4-triazol-5-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate optionally as a solvate and additionally optionally as a hydrate, including crystalline forms, and methods of preparing the (2S,3S)-methyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1H-1,2,4-triazol-5-yl)-4-oxo-1,2,3,4-teirahydroquinoline-5-carboxylate optionally as a coformer salts.
Bibliography:Application Number: KR20177004847