HSP90 HSP70 BIPHENYL AMIDES WITH MODIFIED ETHER GROUPS AS HSP90 INHIBITORS AND HSP70 INDUCERS

• Main Authors: BLAGG BRIAN S.J, ANYIKA MERCY, DOBROWSKY RICK T
• Format: Patent
• Language: English; Korean
• Published: 31.03.2017
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; DERIVATIVES THEREOF; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SUGARS

하기 화학식 (I)의 화합물이 본 명세서에서 제공된다:식 중, n, X, R, R', R, R', R, R', R및 R'는 본 명세서에서 정의된 바와 같다. 이 화합물의 약제학적 조성물이 또한 제공된다. 몇몇 양상에 있어서, 이러한 화합물은 당뇨성 말초 신경병증 또는 암을 비롯한 질환의 치료를 위하여 이용될 수 있다. Provided herein are compounds of the formulas:wherein: n, X2, R3, R3′, R4, R4′, R5, R5′, R6, and R6′ are as defined herein. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds may be used for the treatment of diseases, including diabetic peripheral neuropathy or cancer.