CATIONIC LIPID

• Main Authors: HOSOE SHINTARO, NAOI TOMOYUKI
• Format: Patent
• Language: English; Korean
• Published: 02.03.2017
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

본 발명은, 하기 식 (I)로 표시되는 양이온성 지질, 그리고 이 양이온성 지질 및 핵산을 함유하는 조성물 등을 제공하는 것을 목적으로 한다:식 중, R및 R는 탄소수 8∼24의 알킬 등이고, R은 수소 원자, 탄소수 1∼3의 알킬, 하기 식 (A)(식 중, R및 R는 수소 원자 등이며, n은 2∼6의 정수임), 또는 하기 식 (B)(식 중, R및 R은 수소 원자 등이며, n는 1∼6의 정수임)이며, n은 0∼4의 정수이고, n는 1∼4의 정수이다(단, n이 0이며, n가 1인 경우를 제외함). The present invention provides a cationic lipid represented by the formula (I) wherein R 1 and R 2 each represents alkyl having 8 to 24 carbon atoms or the like; R 3 represents a hydrogen atom, alkyl having 1 to 3 carbon atoms, the formula (A) wherein R 4 and R 5 each represents a hydrogen atom or the like, and n 3 represents an integer from 2 to 6, or the formula (B) wherein R 6 and R 7 each represents a hydrogen atom or the like, and n 4 represents an integer from 1 to 6; n 1 represents an integer from 0 to 4; and n 2 represents an integer from 1 to 4, provided that the case where n 1 is 0 and n 2 is 1 is excluded, and a composition which contains the cationic lipid and a nucleic acid, or the like.