New method for preparation of chiral chromanol derivatives

• Main Authors: LEE, SUNG AH, CHOI, KWANG DO, HEO, SEUNG PYEONG, KWEON, JAE HONG, LEE, JI YUN, KIM, YOUNG JU, KO, DONG HYUN, KIM, EUN SUN
• Format: Patent
• Language: English; Korean
• Published: 14.02.2017
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; THEIR RELEVANT APPARATUS; TRANSPORTING

The present invention relates to a novel production method for a chromanol derivative. According to the production method for the optically active chromanol derivative, the produced chromanol shows high optical purity, and does not require additional purification processes, unlike previously known optical activity reduction reactions. Additionally, since the production method does not involve harsh reaction conditions as well as hazardous reagents, the production method is suitable for the mass-production while ensuring high production yields. 본 발명은 크로마놀 유도체의 신규한 제조방법에 관한 것이다. 본 발명에 따른 광학 활성을 갖는 크로마놀 유도체의 제조 방법은 종래 알려진 광학 활성 환원반응 기술과 달리, 제조되는 크로마놀이 높은 광학순도를 나타내어 별도의 정제 공정을 필요로 하지 않으며, 혹독한 반응 조건을 포함하지 않고 위험한 시약을 사용하지 않기 때문에 대량생산에 유리하고 제조수율 또한 우수한 장점을 가진다.