Method for analyzing related substances of a pharmaceutical composition containing a polymeric carrier

• Main Authors: KIM, HYE RIM, SEO, MIN HYO, KIM, JI YEONG, CHOI, HO JOON, MIN, BUM CHAN
• Format: Patent
• Language: English; Korean
• Published: 08.02.2017
• Subjects: COLORIMETRY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT,POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED,VISIBLE OR ULTRA-VIOLET LIGHT; MEASURING; MEDICAL OR VETERINARY SCIENCE; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; RADIATION PYROMETRY; TESTING

The present invention is to provide a method for analyzing related substances in a pharmaceutical composition containing an amphiphilic block copolymer consisting of a hydrophilic block and a hydrophobic block as a drug carrier, related substances identified by the method, and a method for evaluating a pharmaceutical composition using the same. According to the present invention, impurities in a completed medicine can be precisely analyzed by using related substances of a pharmaceutical composition containing a polymeric carrier and a poorly water-soluble drug as a reference material. 친수성 블록과 소수성 블록으로 구성된 양친성 블록 공중합체를 약물용 담체로서 함유하는 약학 조성물 내의 유연물질을 분석하는 방법, 이에 의해 동정된 유연물질, 및 이를 이용한 약학 조성물의 평가 방법이 제공된다.